All experiments were conducted at Biotoxtech Chungwon, Korea , an institute authorized to perform non-clinical studies under the regulations of Good Laboratory Practice GLP. A single-dose intravenous toxicity study was carried out on 40 6-week-old Sprague-Daley rats. The animals were randomly divided into the following four groups of ten animals each: Gathering 1 G1 was the control bunch, with each monster receiving an intravenous injection of 1.
Mortality, clinical signs, body-weight changes and gross pathological findings were observed as a service to 14 days following a single government of SMS or saline.
Organ weights, clinical chemistry and hematology were analyzed at 14 days. This study was conducted with the approval of the Institutional Animal Ethics Committee. No deaths occurred in any of the four groups,indicating that the lethal dose of SMS in rats is greater than 1. Some changes in weights of male rats betwixt the control arrange and the conjectural groups were observed, but no eloquent changes in the weights of female rats were eminent.
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